ea0034p215 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014
Patel Kashyap
, Foretz Marc
, Campbell David
, Sutherland Calum
, Sakamoto Kei
Regulation of hepatic gluconeogenesis by insulin and glucagon is central to blood glucose homeostasis. It has been proposed that the members of AMP-activated protein kinase (AMPK)-related kinases, the salt inducible kinase (SIK) isoforms, may play a role as signalling mediator in the control of insulin- and glucagon-regulated hepatic gluconeogenesis. However, the exact regulation and contribution of SIKs in hepatic gluconeogenesis is largely elusive. Here we employed selective...